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ACC Upset Watch: Can Clemson take down Louisville as home underdog?

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ACC making its College Football Playoff case (0:40)

This week's Clemson vs Louisville matchup could have playoff implications for the ACC. Heather Dinich explains why the winner will be in the driver's seat heading into playoff time. (0:40)

Week 5 brings some intriguing matchups, none bigger than two that will have major implications in the ACC championship race. In these parts, there always is a chance for an upset (see: Duke over Notre Dame, not even listed last week!)

Notre Dame (1-3) at Syracuse (2-2), noon, ESPN. Line: Notre Dame by 10.5. The Irish are struggling, and now must face a Syracuse team that has the ability to hit big plays with Eric Dungey and Amba Etta-Tawo, who leads the nation with 706 yards receiving (with five touchdown catches). Dungey, by the way, ranks No. 6 in the nation in total passing yards with 1,367. How will the Irish respond after a listless performance in a loss to Duke, with a new defensive coordinator running the show? Syracuse coach Dino Babers will have his team prepared. In describing Notre Dame during his weekly press conference, Babers said, "We're going to get an angry momma bear that's been wounded, that's going to be fighting, clawing and coming out with all they have."

Wake Forest (4-0, 1-0) at NC State (2-1), 3:30 p.m., ACC Network. Line: NC State by 10.5. The Deacs are the only unbeaten team in the state of North Carolina and now face an in-state showdown against the Wolfpack, coming off a bye. Wake Forest has been strong on defense under Dave Clawson, but now the offense is finally coming into its own -- with a run game that is averaging 200 yards per game. Will that keep up against a Wolfpack defensive line that has helped NC State rank No. 28 in rushing defense? NC State has a powerful run game with Matt Dayes, too, and quarterback Ryan Finley has played well. But there is no way the Wolfpack should be overlooking Wake Forest.

North Carolina (3-1, 1-0) at No. 12 Florida State (3-1, 0-1), 3:30 p.m., ESPN. Line: Florida State by 10. Until Florida State figures out a way to fix its porous secondary, the Seminoles could very well end up as a weekly fixture on the Upset Watch. Mitch Trubisky and the North Carolina offense come in off an impressive come-from-behind victory over Pitt. Trubisky had 453 yards passing and has yet to throw an interception this season. Here is a safe bet the Tar Heels will get some big plays in the passing game. Florida State needs to get Dalvin Cook going against a poor rush defense to be able to extend the nation's longest active home win streak (22 and counting).

No. 3 Louisville (4-0, 2-0) at No. 5 Clemson (4-0, 1-0), 8 p.m., ABC. Line: Louisville by 2. The surging Cards take on the defending ACC champions in a game that will determine who has the inside track for not only the Atlantic Division but also a possible College Football Playoff spot. The headlines focus on two of the most dynamic quarterbacks in the country in Lamar Jackson and Deshaun Watson, but the play of both offensive lines will go a long way toward determining who wins. Louisville easily handled Florida State, but the Tigers' defensive front presents its biggest challenge. Clemson is a home underdog for the first time since 2013, when Florida State came to town. The Seminoles ended up winning in a blowout.