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Fantasy predictions for every Week 4 matchup

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How can Newton's O-line save him? (1:04)

Antonio Pierce breaks down the problems in the Panthers' offensive line that have led to multiple sacks on quarterback Cam Newton. (1:04)

Need some help setting your fantasy lineup? NFL Nation reporters are here to help with predictions for every Week 4 game. The Miami Dolphins and Cincinnati Bengals have been excluded after playing on Thursday night.


COLTS AT JAGUARS

Indianapolis Colts

Receiver T.Y. Hilton finally found his rhythm when he had eight receptions for 174 yards and a touchdown against San Diego in Week 3. Hilton has a history of success against Jacksonville. His 39 receptions and 714 yards in his career against the Jaguars are the second most against any team he has faced. Hilton, like the case against the Chargers, has to continue to carry a bigger role until Donte Moncrief (shoulder) returns to the lineup, and he'll do just that against Jacksonville. -- Mike Wells

Jacksonville Jaguars

It's still a good idea to stay away from RBs Chris Ivory and T.J. Yeldon. Ivory has been battling a knee and ankle sprain all week, though he is expected to play against the Colts. The Jaguars just haven't been able to run the ball; they're averaging 55.0 yards a game. Offensive coordinator Greg Olson said the Jaguars have tried a few changes this week to get the run game going, but until they prove they can get it done, you should keep Ivory and Yeldon out of your lineup. -- Mike DiRocco


TITANS AT TEXANS

Tennessee Titans

Kendall Wright will get at least six targets. The receiver is due to return from a hamstring injury that has kept him out of the lineup for the first three games. Even if Delanie Walker returns (hamstring injury), and if Marcus Mariota throws as much to DeMarco Murray as he has early on, the Titans will look to get Wright involved because their receiver output has been lacking so far. -- Paul Kuharsky

Houston Texans

Receiver DeAndre Hopkins will have his biggest game of the season on Sunday against the Titans. In six career games against Tennessee, Hopkins has 40 catches for 696 yards and five touchdowns. With receiver Will Fuller emerging as a legitimate threat, defenses may not be able to double-team Hopkins as much, which could mean a big day for the Pro Bowler. -- Sarah Barshop