We're stepping out on a limb with our picks this week, with at least one writer calling for the upset in all but two games involving ACC teams.
Also, visit our college football PickCenter page for additional information on these games and many more.
Notre Dame at Syracuse
Saturday, noon ET on ESPN
No. 14 Miami at Georgia Tech
Saturday, noon ET on ESPN2
Virginia at Duke
Saturday, 12:30 p.m. ET on ACC Network
Wake Forest at NC State
Saturday, 3:30 p.m. ET on ACC Network
No. 3 Louisville at No. 5 Clemson
Saturday, 8 p.m. ET on ABC
Boston College over Buffalo
Florida State over North Carolina
Pittsburgh over Marshall