ACC Week 5 game picks: Clemson-Louisville and upsets galore

Can Lamar Jackson tame Tigers in massive ACC tilt? (0:32)

The ACC Atlantic Division could be decided Saturday when No. 3 Louisville visits No. 5 Clemson. ESPN college football reporter Chris Low predicts the biggest game of the regular season. (0:32)

We're stepping out on a limb with our picks this week, with at least one writer calling for the upset in all but two games involving ACC teams.

Also, visit our college football PickCenter page for additional information on these games and many more.

Notre Dame at Syracuse
Saturday, noon ET on ESPN

No. 14 Miami at Georgia Tech
Saturday, noon ET on ESPN2

Virginia at Duke
Saturday, 12:30 p.m. ET on ACC Network

Wake Forest at NC State
Saturday, 3:30 p.m. ET on ACC Network

No. 3 Louisville at No. 5 Clemson
Saturday, 8 p.m. ET on ABC

Unanimous picks:

Boston College over Buffalo

Florida State over North Carolina

Pittsburgh over Marshall

Current standings:

Shanker: 39-8

Adelson: 36-11

Fortuna: 36-11

Hale: 36-11