8:20 p.m. ET | NBC
Matchup rating: 79.8 | Spread: KC -6.5 (56.5)
What to watch for: Who will show up for the Raiders on defense? Las Vegas had a statement game defensively in the victory at Arrowhead Stadium last month, but 10 of the 11 players on their reserve/COVID-19 list are defensive players. Defensive end Clelin Ferrell, who tested positive, is likely out, but the rest, including safety Johnathan Abram and defensive tackles Maliek Collins and Johnathan Hankins, will be eligible to play should they test negative this weekend. And without a stout defense, the Raiders have no shot against the powerful Kansas City offense. -- Paul Gutierrez
Bold prediction: The Raiders will have under their season average of 370 yards and get zero plays of more than 40 yards. This might not sound very bold, but consider that Las Vegas had five plays of 40-plus yards and almost 500 yards of total offense the previous time they played the Chiefs. And no matter which team wins, there will be no victory lap around the stadium afterward. -- Adam Teicher
Stat to know: Raiders quarterback Derek Carr has a 94 QBR against the blitz this season, which ranks second behind Kansas City QB Patrick Mahomes (98). The Chiefs have blitzed on 34% of opposing QB dropbacks this season, the seventh-highest rate in the NFL.
What to know for fantasy: Prior to the bye, Chiefs wide receiver Tyreek Hill had consecutive 25-plus-point games for the third time in his career. He now faces a defense that Mahomes has gashed throughout his career (26.2 fantasy points per game against the Raiders). See Week 11 rankings.
Betting nugget: Las Vegas is 5-0 ATS in its past five games against AFC West opponents. Read more.
Teicher's pick: Chiefs 33, Raiders 28
Gutierrez's pick: Chiefs 35, Raiders 17
FPI prediction: KC, 75.8% (by an average of 9.4 points)
Matchup must-reads: Leaving Las Vegas? Carr is simply loving Las Vegas ... Why Chiefs' Mahomes-to-Kelce connection is the best of its time ... Gruden: Raiders have little time to savor win with rested Chiefs next ... Raiders buses' victory lap at Arrowhead irritated Reid ... Heath jump-started Raiders' rout of Broncos with prophesied pick ... Mahomes motivated to avoid season sweep