4:25 p.m. ET | CBS
Matchup rating: 73.5 | Spread: KC -8.5 (47.5)
What to watch for: Keep an eye on the turnover margin. In losing five of six games to the Chiefs since Anthony Lynn took over as head coach, the Chargers' offense has committed 17 turnovers, and their defense has generated only two of them. "That's ridiculous," Lynn said. "You're just not going to beat this team that way." -- Alden Gonzalez
Bold prediction: The Chiefs, who intercepted 15 passes in their last six games against the Chargers, will get a couple of picks against Tyrod Taylor. The Chiefs got consistent pressure on the Texans' Deshaun Watson last week, and look for them to have similar success against Taylor, who isn't as prone to throwing interceptions as ex-Chargers QB Philip Rivers but will be forced into mistakes on Sunday. -- Adam Teicher
Stat to know: Chiefs quarterback Patrick Mahomes is 8-0 with a 89 Total QBR and 26 passing touchdowns in the month of September, all the best in the NFL since the start of the 2018 season. And the Chiefs have won 10 straight games overall (including playoffs), the second-longest streak in franchise history (11 straight in 2015 season).
What to know for fantasy: Chargers running back Austin Ekeler has converted just 15.4% of his career red-zone carries (the RB average is 18%), so it's worth noting that rookie Joshua Kelley out-touched him in the red zone, 4-3, in Week 1. See Week 2 rankings.
Betting nugget: The Chiefs have covered in their last seven divisional games. Read more.
Teicher's pick: Chiefs 27, Chargers 20
Gonzalez's pick: Chiefs 31, Chargers 24
FPI prediction: KC, 71.0% (by an average of 7.9 points)