HUNTINGTON, W.Va. -- Lamar Jackson threw five touchdown passes, ran for two more scores and No. 3 Louisville breezed past Marshall 59-28 on Saturday night.
Jackson capped off a September to remember with another solid effort against an overmatched opponent.
The sophomore completed 24 of 44 passes for a career-high 417 yards against a Marshall secondary whose most experienced player had five starts. Jackson also ran for 62 yards.
Louisville (4-0) didn't slow down against a nonconference opponent on the road a week after beating Florida State 63-20 at home.
The Cardinals raced to a 35-7 halftime lead on Marshall and cruised in the second half to break a four-game losing streak to the Thundering Herd. Jackson's scoring passes covered 71, 8, 30, 8 and 51 yards.
Marshall (1-2) was limited to 207 yards of offense in the first start for freshman quarterback Garet Morrell. Chase Litton missed the game with an undisclosed injury that was announced an hour before kickoff.
LOUISVILLE: Jackson simply hasn't been stopped, although Marshall's pass rush at times forced him into inaccurate throws and his streak of five straight 100-yard rushing games dating to last season came to an end. After four games, he's thrown 13 TD passes and run for 12 more scores.
MARSHALL: The Thundering Herd need Litton back in a hurry and could use some help on defense after allowing 124 points in their last two games.
With No. 2 Ohio State idle, Louisville could gain some votes in the AP Top 25 poll but it might not be enough to overtake the Buckeyes.
LOUISVILLE: Heads to No. 5 Clemson with a chance to strengthen its perch at the top in the Atlantic Coast Conference's Atlantic Division after beating No. 13 Florida State last week.
MARSHALL: Closes out nonconference play at Pittsburgh.