1 p.m. ET | Fox
Matchup rating: 53 | Spread: SF -7 (42.5)
What to watch for: It's a battle of two relatively inexperienced quarterbacks -- the 49ers' Jimmy Garoppolo and the Jets' Sam Darnold (27 career starts each). Garoppolo (21-6) has done more winning than Darnold (11-16), who hasn't had the same talent and coaching around him as his counterpart. How each performs on Sunday will be a difference-maker for two passing offenses looking to get going after Week 1 losses. -- Rich Cimini
Bold prediction: 49ers rookie receiver Brandon Aiyuk will go over 100 yards in his NFL debut. Aiyuk is back from a hamstring injury, and after a poor showing for the Niners' receivers last week, Aiyuk will get plenty of chances to show why coach Kyle Shanahan coveted him in the first round of the NFL draft. -- Nick Wagoner
Stat to know: San Francisco tight end George Kittle was held to 44 receiving yards on four catches in Week 1. But he hasn't had back-to-back games under 50 yards since 2017.
What to know for fantasy: No player in the NFL accounted for a greater percentage of his team's Week 1 scrimmage yards than Jamison Crowder (45.3%). But whether he suits up will be something to keep an eye on. See Week 2 rankings.
Betting nugget: Since 2013, west coast teams are 8-2-1 ATS when favored by at least 7 points in 1 p.m. ET games. Read more.
Wagoner's pick: 49ers 31, Jets 20
Cimini's pick: 49ers 24, Jets 20
FPI prediction: SF, 61.1% (by an average of 4.0 points)
Matchup must-reads: It's hitting us pretty hard right now': Sherman latest 49ers injury ... Jets CEO Christopher Johnson expresses confidence in Gase, Darnold ... 49ers' crown means little in loaded NFC West ... If Darnold sputters, Jets will face complex question: Trevor Lawrence? ... Jets place RB Bell on IR with hamstring injury, sign Ballage