Sunday, 4:25 p.m. ET | CBS
Matchup rating: 97.2 | Spread: KC -3 (51.5)
What to watch for: It's two of the NFL's elite teams, both trying to secure the crucial No. 1 seed in their conferences. The Chiefs' No. 1-ranked offense meets the Saints' No. 2-ranked defense. Oh, and there's a chance that Drew Brees could return to the lineup just in time for an epic QB matchup against Patrick Mahomes. There might not be a better game on the NFL's regular-season schedule all year. -- Mike Triplett
Bold prediction: The Chiefs will force the Saints into at least two game-altering turnovers. The suddenly revived Chiefs pass rush had four sacks against the Dolphins last weekend and will pressure the Saints' quarterback -- whether it's Brees or Taysom Hill -- into some mistakes. Keep an eye on Chiefs safety Tyrann Mathieu, who has four interceptions over the past three games. -- Adam Teicher
Stat to know: Mahomes has thrown for at least 315 yards in six straight games, tied with Brees (2012-13) and Rich Gannon (2002) for the longest such streak in NFL history. And according to the Elias Sports Bureau, his 2,309 yards over his past six games is the most over any six-game span in NFL history.
Playoff/draft picture: To clinch the AFC's No. 1 seed and home-field advantage throughout the playoffs, the Chiefs need a win and losses by both the Steelers and Bills. And the Saints could clinch the NFC South with a win or a Buccaneers loss.
What to know for fantasy: Chiefs running back Clyde Edwards-Helaire has been held under 40 rushing yards in four of his past five games, and despite being a fantasy first-rounder, he has just two top-10 performances this season. See Week 15 rankings.
Betting nugget: Kansas City has won five consecutive one-score games, though it has failed to cover in all five. It is the first team to win but not cover five straight since the 1986 Patriots. Read more.
Teicher's pick: Chiefs 26, Saints 20
Triplett's pick: Chiefs 27, Saints 24
FPI prediction: KC, 55.2% (by an average of 1.8 points)
Matchup must-reads: How long would Chiefs QB Mahomes need to surpass passing records of Saints' Brees? ... Saints just missed on Mahomes in 2017, but reshaped the franchise anyway ... Chiefs, Mahomes continue "love-hate relationship" with Hard Rock Stadium ... Payton: Brees return depends on how week goes ... Turnovers continue to cloud Hill's future as Saints quarterback