How does Clady loss impact run game?

The Denver Broncos placed left tackle Ryan Clady on injured reserve, ending his season and throwing a major kink into their offense. Clady had started 85 consecutive games dating back to the end of the 2007 regular season. Clady's numbers are impressive: 1 sack allowed in over 1,100 snaps and four holding penalties all of last season. Though much has been written about how the loss impacts the passing offense, what could it mean for Knowshon Moreno and company?