How big is Duane Brown's absence?

The Houston Texans might be without offensive tackle Duane Brown for the second straight week when his team takes on the Seattle Seahawks this Sunday. Brown has a turf toe injury and is trying not to rush back. In Houston, Brown has played four full seasons and missed only a quarter of his fifth. Matt Schaub is not used to being without Brown on his blind side. How much of an impact will his absence be if he can't suit up again?