Any hope for Bills RBs in Week 5?

The short week for the Thursday night game participants is always unkind, especially to those with injuries. A unit that will be hit especially hard this week is the Buffalo Bills backfield. C.J. Spiller (ankle) and Fred Jackson (sprained MCL) are both hobbled and their statuses for tomorrow's tilt against the Cleveland Browns is uncertain. What can we glean about their collective productivity in the pivotal Week 5 game?