Monday, 5 p.m. ET | Fox/NFL
Matchup rating: 85.5 | Spread: KC -5 (57.5)
What to watch for: Bills wide receiver Stefon Diggs is averaging a career-high 101.8 yards per game in 2020, good for second in the NFL. The Chiefs, on the other hand, have allowed two 100-yard receivers through five games this season. Look for quarterback Josh Allen and Buffalo offensive coordinator Brian Daboll to push that number to three come Monday. -- Marcel Louis-Jacques
Bold prediction: Running back Clyde Edwards-Helaire will again become a prominent part of the Chiefs' offense and will score his first touchdown since Week 1. While he might not have a huge game against Buffalo's rushing defense, the Chiefs will feature him more than they did last weekend against the Raiders, when he had 10 carries and three catches. The Chiefs abandoned their running game far too early against Las Vegas and won't make that mistake two weeks in a row, particularly with Sammy Watkins out of the lineup. -- Adam Teicher
Stat to know: Kansas City quarterback Patrick Mahomes began his 2018 MVP season by completing 64% of his passes for 1,513 yards, 14 touchdowns, two interceptions and an 86.1 Total QBR through five games. That stat line isn't too far from what Allen has done through five games this season: 69% passing, 1,589 yards, 14 touchdowns, three interceptions and an 85.2 Total QBR.
What to know for fantasy: Mahomes has 235 passing yards, 20 rushing yards and multiple passing scores in four straight games. He is the first quarterback with a streak like that since Aaron Rodgers in 2016. See Week 6 rankings.
Betting nugget: Kansas City is 7-1-1 ATS in Monday games under Andy Reid and 4-0-1 ATS on Monday night with Mahomes at quarterback. Read more.
Teicher's pick: Chiefs 31, Bills 27
Louis-Jacques' pick: Chiefs 38, Bills 34
FPI prediction: KC, 67.5% (by an average of 6.2 points)
Matchup must-reads: Mathieu is changing the game ... Missing starters evident in Bills' humbling loss on national stage ... Source: Hamstring injury could sideline Chiefs WR Watkins a couple of games ... Biggest surprises for every AFC team thus far in the 2020 season