4:25 p.m. ET | Fox
Matchup rating: 76.6 | Spread: SEA -6 (46)
What to watch for: They're a long shot, but the Seahawks still have a chance to steal the NFC's No. 1 seed with some help elsewhere, which means they'll be hungry to finish strong here. The 49ers enjoyed playing the spoiler role last week for Arizona and would love nothing more than to make their biggest rival's postseason path more difficult. Considering that three of San Francisco's six wins this season have come within the division, don't be surprised if the 49ers keep it closer than the last meeting between these teams. -- Nick Wagoner
Bold prediction: Seahawks cornerback D.J. Reed Jr. will make another big play against his former team. He picked off Jimmy Garoppolo in his Seahawks debut in Week 9, a game he had circled on his calendar since the 49ers waived him in August. He has played his way into a starting job at right cornerback since and has been a part of Seattle's defensive turnaround. As the team's primary punt returner, it seems only a matter of time before he breaks off a long return. -- Brady Henderson
Stat to know: The Seahawks have allowed an NFL-low 13.7 points per game since Week 11, going 5-1 in that stretch. They allowed 29.6 per game through the first 10 weeks of the season, which ranked 28th in the league.
Playoff/draft picture: The Niners won't be returning to the playoffs, but the Seahawks have locked up the NFC West and can clinch the No. 1 seed with a win, a New Orleans loss and a Green Bay loss. Their FPI chances to be the No. 1 seed in the NFC sit at 5.5%. The 49ers are currently projected to have the 14th draft pick, with 1.4% chance at clipping the top 10.
What to know for fantasy: Seattle quarterback Russell Wilson carried you through the first two months of the season, but, on a per-game basis, he is QB16 since Week 10 (16.2 points per game, ranking behind Philip Rivers and Baker Mayfield). See Week 17 rankings.
Betting nugget: Seattle is 14-4 ATS against San Francisco since 2012, including a cover in Week 8 this season. Read more.
Wagoner's pick: Seahawks 23, 49ers 20
Henderson's pick: Seahawks 26, 49ers 17
FPI prediction: SEA, 60.1% (by an average of 3.4 points)
Matchup must-reads: Injuries, ominous skies and relocation: 49ers' nightmare season finally comes to close ... What a difference a year makes: Seahawks' backfield at full strength entering January ... Shanahan maps out future with Garoppolo ... Playing 'lights out': Seahawks' defensive turnaround key to NFC West title