First place in the AFC South will be on the line, with both teams entering play at 6-4.
ESPN betting analyst Joe Fortenbaugh and fantasy's Mike Clay combine to offer their best bets for the matchup of division rivals.
Note: Odds courtesy of Caesars Sportsbook, unless otherwise noted. Odds as of Wednesday.
Indianapolis Colts at Houston Texans (-4, 45.5)
Fortenbaugh: The Texans were thoroughly humiliated on Sunday in Baltimore, to the tune of a 34-point thrashing that has to raise some eyebrows, especially when you consider the fact that Houston head coach Bill O'Brien and his team had two weeks to get ready for the matchup.