Eliminator Challenge is one of the simplest and most fun games during the NFL season. Pick one team to win each week. If that team wins, you advance to the next week. Lose once, and you're out. The only caveat is you cannot pick the same team twice.
The key is to find a good balance of picking winners while also not mortgaging future weeks by burning up all your good teams for later. Injuries and teams either overachieving or underachieving will always open up more opportunities later, so early in the season there is less incentive to worry about saving teams.
To make these recommendations, I look at a combination of ESPN's Football Power Index (FPI), point spreads from Caesars Sportsbook, injury reports, upcoming schedules and any other stats that can potentially provide an edge.