| Thursday, September 21 | |||||
| TIME (ET) | MATCHUP | TV | PPV | MOBILE | TICKETS |
| 7:30 PM | Temple at No. 21 South Florida |   | |||
| Friday, September 22 | |||||
| TIME (ET) | MATCHUP | TV | PPV | MOBILE | TICKETS |
| 8:00 PM | Virginia at Boise State |  | |||
| 10:30 PM | No. 23 Utah at Arizona | FOX Sports 1 | |||
| Saturday, September 23 | |||||
| TIME (ET) | MATCHUP | TV | PPV | MOBILE | TICKETS |
| 12:00 PM | UNLV at No. 10 Ohio State | BTN | |||
| 12:00 PM | NC State at No. 12 Florida State |  | |||
| 12:00 PM | Kent State at No. 19 Louisville | ACC Network Extra | |||
| 12:00 PM | Texas Tech at Houston | | |||
| 12:00 PM | Army at Tulane | CBS Sports Network | |||
| 12:00 PM | Texas A&M vs. Arkansas* | | |||
| 12:00 PM | UMass at Tennessee |  | |||
| 12:00 PM | West Virginia at Kansas |  | |||
| 12:20 PM | Pittsburgh at Georgia Tech | ACC Network Extra | |||
| 1:30 PM | New Mexico at Tulsa |  | |||
| 2:00 PM | Old Dominion at No. 13 Virginia Tech | ACC Network Extra | |||
| 2:00 PM | Idaho at South Alabama | | |||
| 2:00 PM | Ohio at Eastern Michigan | | |||
| 3:00 PM | UCF at Maryland | FOX Sports 1 | |||
| 3:30 PM | No. 1 Alabama at Vanderbilt | CBS | |||
| 3:30 PM | Boston College at No. 2 Clemson | | |||
| 3:30 PM | No. 5 USC at California | | |||
| 3:30 PM | No. 16 TCU at No. 6 Oklahoma State | | |||
| 3:30 PM | Toledo at No. 14 Miami | ACC Network Extra | |||
| 3:30 PM | Rutgers at Nebraska | BTN | |||
| 3:30 PM | Georgia Southern at Indiana | BTN | |||
| 3:30 PM | Wake Forest at Appalachian State | | |||
| 3:30 PM | Duke at North Carolina | | |||
| 3:30 PM | Louisiana Tech at South Carolina | | |||
| 3:30 PM | Miami (OH) at Central Michigan | | |||
| 3:30 PM | Cincinnati at Navy | CBS Sports Network | |||
| 4:00 PM | No. 8 Michigan at Purdue | FOX | |||
| 5:00 PM | Louisiana Monroe at Louisiana | | |||
| 6:00 PM | Nevada at No. 18 Washington State | Pac-12 Network | |||
| 6:00 PM | Akron at Troy | | |||
| 6:00 PM | Georgia State at Charlotte | ||||
| 6:30 PM | No. 3 Oklahoma at Baylor | FOX Sports 1 | |||
| 6:30 PM | Western Illinois at Coastal Carolina | | |||
| 6:30 PM | UAB at North Texas | ||||
| 7:00 PM | No. 17 Mississippi State at No. 11 Georgia | | |||
| 7:00 PM | No. 22 San Diego State at Air Force | CBS Sports Network | |||
| 7:00 PM | Syracuse at No. 25 LSU | | |||
| 7:00 PM | Ball State at Western Kentucky | ||||
| 7:00 PM | Florida Atlantic at Buffalo | | |||
| 7:00 PM | Bowling Green at Middle Tennessee | | |||
| 7:00 PM | Arkansas State at SMU | | |||
| 7:00 PM | Wagner at Western Michigan | | |||
| 7:30 PM | No. 4 Penn State at Iowa | | |||
| 7:30 PM | No. 15 Auburn at Missouri | | |||
| 7:30 PM | No. 20 Florida at Kentucky | | |||
| 7:30 PM | Florida Intl at Rice | ||||
| 7:30 PM | Utah State at San José State | ||||
| 7:30 PM | UT San Antonio at Texas State | | |||
| 8:00 PM | UTEP at New Mexico State | | |||
| 8:00 PM | Southern Illinois at Memphis | | |||
| 8:00 PM | Notre Dame at Michigan State | FOX | |||
| 10:00 PM | No. 7 Washington at Colorado | FOX Sports 1 | |||
| 10:00 PM | No. 24 Oregon at Arizona State | Pac-12 Network | |||
| 10:15 PM | Hawai'i at Wyoming | | |||
| 10:30 PM | UCLA at Stanford | | |||
| Sunday, September 24 | |||||
| TIME (ET) | MATCHUP | TV | PPV | MOBILE | TICKETS |
| 12:00 PM | East Carolina at Connecticut | | |||