Picks for Week 2's biggest games

Steele: Week 2 picks | Harris: Best bets | CFB PickCenter | Betting guide

Each week during the 2014 college football season I will offer my picks and scores for the biggest games in addition to a handful of other key matchups. Last week, my picks went 8-2 straight up and 5-5 against the spread.

Week 2 features perhaps the biggest nonconference game of the year between Michigan State and Oregon, an early key Pac-12 game between USC and Stanford and the final chapter in the storied Michigan-Notre Dame rivalry.

No. 7 Michigan State Spartans at No. 3 Oregon Ducks (-12)

Saturday at 6:30 p.m. ET

This is arguably the biggest nonconference game of the 2014 season matching two top-10 teams. The home team is 4-0 in the series, and the most recent meeting came in 1999, a 27-20 Michigan State win.

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Both teams are coming off dominating wins over FCS opponents last week. Oregon crushed South Dakota 62-13 highlighted by QB Marcus Mariota's four touchdowns in the first half. The Spartans' 45-7 win over Jacksonville State included an injury scare to QB Connor Cook, who was very efficient, going 12-of-13 for 285 yards and three touchdowns. It also saw their defense allow their first touchdown at home since Oct. 12 of last year, a span of 216 minutes of game time.