Coxie unexpectedly left the team in the middle of last week, coach Ryan Silverfield told reporters Monday, after confirming Coxie's absence following Memphis' win Saturday over UCF.
Coxie had 16 receptions for 175 yards and a touchdown in Memphis' first two games. The senior recorded 148 receptions for 2,450 yards and 16 touchdowns in the previous two seasons, twice earning second-team All-American Athletic Conference honors.
He is the second prominent offensive player to leave the team, as running back Kenneth Gainwell in August decided to opt out of the season.
Memphis (2-1, 1-1 AAC) is scheduled to host Temple on Saturday.