"Trevor has authorized us this evening to announce that he has tested positive for COVID-19 and is now in isolation," Clemson coach Dabo Swinney said in a statement Thursday night. "He is doing well with mild symptoms but will not be available for this week's game against Boston College.
"While we certainly will miss Trevor, this is an opportunity for other guys to step up and we're excited about competing against a very good BC team on Saturday. Go Tigers."
Lawrence released a statement on social media, saying his symptoms were mild and that "the only thing that hurts is missing an opportunity to be with my teammates this weekend and play the game I love."
Lawrence is a front-runner for the Heisman Trophy and has not missed a game in three seasons at Clemson.
When Lawrence was announced as out, Clemson was listed as a 29.5-point favorite over Boston College. The game was taken off the board before being reposted with the Tigers as a 24-point favorite.
Lawrence's positive was among three from Clemson athletes and one from a staff official out of 1,343 total tests from student-athletes and staff, the school said.
Lawrence's COVID-19 test was taken Wednesday. Under the rules established by the ACC's medical advisory group, any player who tests positive for COVID-19 must isolate for at least 10 days after the test before returning to practice, assuming the player is no longer showing symptoms. That would also put Lawrence at risk of missing the top-ranked Tigers' Nov. 7 showdown at No. 4 Notre Dame.
While Lawrence has never missed a start for Clemson since taking over the offense in September 2018, he did go down with an injury in the first half of his first start against Syracuse that year. Chase Brice came on in relief and led a fourth-quarter comeback that preserved the Tigers' perfect record, and Clemson went on to win the national championship.
Brice is now the starter at Duke after transferring this offseason. That likely leaves true freshman D.J. Uiagalelei as the presumed starter for the Tigers (6-0, 5-0 ACC). Uiagalelei has seen limited action, completing 12 of 19 passes for 102 yards with two rushing touchdowns. He was the No. 3 overall QB recruit in the country for 2020.
Lawrence was in the midst of a stellar start to the 2020 season, completing 71% of his throws with 21 total touchdowns through six games.
Information from ESPN's Andrea Adelson and Holly Rowe was used in this report.