With his receiving touchdown in the first quarter, Etienne has now scored a touchdown in 42 games, breaking a tie with Donnel Pumphrey (2013-16) for most in FBS history.
Etienne then broke the ACC career rushing record when he went over 43 yards on the ground in the third quarter, passing NC State running back Ted Brown, who set the mark of 4,602 yards from 1975 to '78.
"When it happened, it was an amazing feeling, but we were still down at that point, so we were looking at each other like man now we've got to win this thing," Etienne said. "We can't have this great record with an L, so we were focused on scoring and changing the game. So now I have this record, and the W and great comeback, it defines who the team is. It's great how it ended."
Indeed, Etienne scored the go-ahead touchdown on that drive, on a 17-yard run straight up the middle.
A two-time ACC Player of the Year, Etienne returned to Clemson for his senior season and is a big reason the Tigers have been a College Football Playoff contender the past two years.
Etienne ended Saturday's game with two touchdowns and a career-high 264 all-purpose yards.
"There's been some great, great running backs come through Clemson, and also through this league," coach Dabo Swinney said. "That is an incredible record. I'm just proud of Travis and just his total development. He's such a complete player now and he was a one-dimensional player when he first got here, and now he's a Swiss army knife. He can do it all."