Karabell's first look at Week 7: Time to run away from the Chiefs?

LeSean McCoy and the rest of the Kansas City backfield have been albatrosses for fantasy managers over recent weeks. Jay Biggerstaff-USA TODAY Sports

The Kansas City Chiefs entered Week 6 with the universally recognized top quarterback and tight end in the sport, plus a productive wide receiver returning from injury.

What Andy Reid's team lacked was a relevant running game -- and things did not improve Sunday with a second consecutive home loss, this time to the intriguing Houston Texans. The Chiefs' running backs have become a source of frustration for fantasy managers, who are wondering not only which ones to trust, but perhaps also whether any are truly reliable enough to deserve more than borderline flex attention.