First look at fantasy football for NFL Week 4: Uncertain RB situations, Mike Williams and more

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Tampa Bay Buccaneers quarterback Tom Brady seems all but guaranteed to make history in the highlight game of Week 4, and he will do so in a stadium where he has made lots of history previously. Brady, who famously led the New England Patriots to unparalleled success for two decades, makes his road return to Massachusetts on "Sunday Night Football" versus legendary coach Bill Belichick and his former franchise. Brady needs a mere 68 passing yards to break Drew Brees' NFL mark, and he can do so back in New England. We must watch!

For fantasy purposes, however, the quarterbacks are not really the story of this game. After all, Brady is universally rostered, and for Week 3, a tough road game against the Los Angeles Rams, he was active in more than 75% of ESPN standard leagues. That figure should be higher in Week 4. Put simply, after 56.8 PPR points in three games, Brady forces us to play him. Then there is Patriots rookie Mac Jones, rostered in 17% of leagues and barely active in any of them, and that should not change against the challenging Buccaneers defense, either.

No, this matchup -- at least in fantasy -- might be about the running backs.