Best, worst Week 11 matchups

Peyton Manning faces a tough challenge against the Chiefs' defense on Sunday night. Justin Edmonds/Getty Images

After a few soft weeks, the Week 11 schedule features three crucial matchups of marquee offensive players going up against three of the best defenses in the league.

San Francisco travels to New Orleans, where Drew Brees often fills up the stat sheet. The Saints just set the NFL record with 40 first downs against Dallas, and Brees has multiple touchdown passes in his last five games against the 49ers (but he did throw two pick-sixes in last year's 31-21 loss).

Every NFL fan should be anticipating Denver's No. 1 scoring offense (41.2 PPG) against Kansas City's No. 1 scoring defense (12.3 PPG). This column has been high on starting every Denver skill player while sitting most of the ones playing against Kansas City, so this creates a dilemma. We detail the matchup below.

To close things out, on "Monday Night Football," the Patriots travel to Carolina. The Panthers have the No. 1 defense, according to Football Outsiders' DVOA efficiency metric. Tom Brady found his groove (or his "Gronk") against Pittsburgh, but after a bye week, it's still hard to trust the New England offense this season. Carolina's secondary is suspect and this should be the best passing attack it sees all season outside of games with New Orleans, so it's an intriguing challenge for an emerging contender.

Here are the best and worst fantasy matchups for Week 11:

(Note: references to defensive rankings for the pass and run are based on Football Outsiders' DVOA metric, explained here).


Case Keenum (plus-5 points)

Last week, Keenum was deemed a bad play in Arizona, yet he still produced 19 fantasy points. Keenum is a good game or two away from elite status, as he's actually fourth in fantasy points per game (23.3) among quarterbacks this season. With two games looming against Jacksonville, pick him up while you can.