Kyle Stout's 3-pointer with 16:54 remaining put the Leopards (3-2) ahead 51-49 and they never trailed again. His basket started a 15-6 run that Penn (2-2) never recovered from.
Lafayette plays Fairleigh Dickinson at home on Sunday. Penn plays Providence on the road on Saturday.
For more AP college basketball coverage: https://apnews.com/Collegebasketball and http://twitter.com/AP-Top25
Elements of this story were generated by Automated Insights, http://www.automatedinsights.com/ap, using data from STATS LLC, https://www.stats.com
Gonzaga Bulldogs remain No. 1, Baylor Bears back to No. 2 in AP Top 25
Gonzaga remains entrenched at No. 1 in The Associated Press men's college basketball poll in its bid to go wire-to-wire. Baylor moved back into the No. 2 slot after dropping a spot last week.
Teague gets Baylor off to a hot start with two quick triples
MaCio Teague drains back-to-back 3-pointers to give Baylor an 8-0 lead on Texas Tech.
Edwards hyped after draining 3-pointer
Texas Tech's Terrence Shannon Jr. tosses a cross-court pass to Kyler Edwards for a big 3-pointer.