Colgate (7-1, 7-1 Patriot League) led 36-32 at halftime, and after Austin Butler's layup with 8:05 remaining brought the Crusaders within 58-50, Colgate went on a 14-4 run to put it out of reach.
Jeff Woodward added 10 points for Colgate, which now has won six straight, the last four of which have come against the Crusaders.
Colgate's average margin of victory has been 19 points against Holy Cross.
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College basketball Power Rankings: Duke is the new No. 1, three new teams climb into top 16
Duke's win over Gonzaga resets the rankings, and a number of other Feast Week results alter the men's college basketball landscape.
Morgan State, Hampton look to end skids
Morgan State (2-5) vs. Hampton (2-5)
Christon, Grambling St. host Norfolk State
Norfolk State (7-1) vs. Grambling State (2-4)