Wilkes made two of Florida State's four 3-pointers during a 17-3 run for a 22-7 lead and the Seminoles led by double figures for the rest of the first half. Louisville got within 57-49 with 11:34 remaining in the second half, but Balsa Koprivica answered with a dunk to start an 8-0 run.
Malik Osborne added 12 points, Rayquan Evans scored 11 and Scottie Barnes 10 for Florida State (8-2, 4-1 ACC), which shot 50% from the field including 9 of 21 from 3-point range. M.J. Walker had 10 assists and five rebounds, but was just 1-of-7 shooting for two points. Anthony Polite, averaging 9.6 points, did not play.
Florida State won its fourth consecutive game against Louisville — the Seminoles longest winning streak against the Cardinals since the series began in the 1968-69 season.
Florida State is scheduled to host No. 20 Clemson on Saturday. Louisville is set to face Duke on Saturday in the second of three straight home games.
NCAA tournament Bubble Watch: Michigan State has played its way into contention
On the outside looking in most of the season, Michigan State has played its way into tourney consideration.
Prairie View A&M wins 55-54, win streak now 10
— D'Rell Roberts' three-point play with 1:43 remaining provided the winning points as Prairie View A&M defeated Alabama A&M 55-54 on Saturday for its 10th straight victory.
Massner carries Northwestern St. past SE Louisiana 79-61
— Trenton Massner registered 15 points and eight rebounds as Northwestern State got past Southeastern Louisiana 79-61 on Saturday.