Naz Bohannan and PJ Hall added 10 points apiece for Clemson (5-2).
Alex Hemenway hit a 3-pointer to give Clemson the lead for good and spark a 12-2 run that made it 26-17 with 4 minutes left in the first half. Jamir Moore answered with a 3-pointer for Buccaneers but Honor made a 3 and then converted a three-point play before Dawes hit a 3-pointer to give the Tigers a 30-15 lead about 2 minutes later.
Charleston Southern (2-4) trailed by double figures the rest of the way and Parker Fox made a 3 to give Clemson its biggest lead at 87-50 with 2:51 to play.
Clemson shot 49% from the field, made 12 of 29 (41%) from 3-point range, outrebounded Charleston Southern 44-34 and outscored the Buccaneers 42-16 in the paint. The Tigers forced 17 turnovers with nine steals — three by David Collins and two apiece by Honor and Hunter Tyson.
The Tigers were coming off back-to-back losses to No. 16 St. Bonaventure and West Virginia at the Charleston Classic.
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