Chandler, a freshman guard, had seven assists and seven steals. Powell, a transfer from Auburn, came off the bench to hit all five of his 3-point attempts.
Victor Bailey added 14 points and Santiago Vescovi had 13 for the Volunteers (5-1).
Tennessee held Presbyterian scoreless for the final 4:53 of the first half. During that stretch, the Vols scored 17 straight points, leading 45-21 at the break. Tennessee went 9 for 14 (64.3%) on 3-pointers in the first half.
Presbyterian: The Blue Hose arrived in Knoxville with their best record since they joined Division I in 2012. They hope playing a power like Tennessee will be beneficial down the road.
Tennessee: The Vols need Josiah-Jordan James to be healthy in time for the meat of their schedule. They have depth, but his versatility is a potent weapon. He missed his third straight game Tuesday with a finger ligament problem on his left hand.
Presbyterian: After its quick visit among the nation's elite in Knoxville, the Blue Hose return to Clinton, South Carolina, for a Friday night meeting with Bob Jones University.
Tennessee: The Vols have a couple tough tests on the near horizon. They play at Colorado on Saturday. On Dec. 7, they face Texas Tech in the Jimmy V Classic at Madison Square Garden.
Land carries St. Francis (Pa.) past Sacred Heart 85-74
— Maxwell Land tied his career high with 20 points as St. Francis (Pa.) beat Sacred Heart 85-74 on Sunday.
Dickinson pushes Michigan in 2nd half, beats Indiana 80-62
— Hunter Dickinson scored 18 of his 25 points in the second half and Michigan hit 11 3-pointers to pull away and post a convincing 80-62 win at Indiana on Sunday.
Hodge lifts Cleveland State over Robert Morris 75-68
— D'Moi Hodge had 22 points as Cleveland State topped Robert Morris 75-68 on Sunday.