"My decision has nothing to do with the team or coaches, they're always going to be family to me," Santos-Silva wrote in a statement posted on his Instagram page. "I'm just doing what I feel is the best option and decision for my future."
Earlier this month, Santos-Silva said he was declaring for the NBA draft.
In 31 games last season, he led VCU with 12.8 points and 8.9 rebounds per game.
Santos-Silva started 64 games for the Rams the past two seasons. In 2019, he was named to the Atlantic 10 all-tournament team.