They liked what they found out, too.
"We got enough talent here to beat (anybody) in the league," Segura said.
The Phillies won 5-4 in 10 innings in the series opener Monday night. They also held the lead each of the previous two days, only to falter down the stretch. But they managed to hold off the Cubs in the finale behind Hector Neris' adventurous four-out save.
"He had the gutsiest performance possible out there," Philadelphia manager Gabe Kapler said.
After pitcher Tyler Chatwood's pinch-hit double got Chicago within two in the ninth, Neris struck out Addison Russell and retired Victor Caratini on a fly ball to left to close out his eighth save in eight chances. Neris entered with runners on first and second in the eighth and retired Javier Baez on a deep fly ball to left.
"He stayed in there and battled and got the outs that we needed," McCutchen said. "That's all you can ask for from a closer."
Anthony Rizzo and Kyle Schwarber homered for Chicago, which had won three of four. Rizzo finished with four hits and three RBI, but the NL Central-leading Cubs were unable to overcome a second consecutive shaky performance by Lester (3-3).
Realmuto gave Philadelphia a 4-0 lead in the third when he belted a solo drive over the bleachers in left for his seventh homer. The Phillies added three more in the fourth, taking advantage of some shoddy fielding by Chicago.
With Sean Rodriguez aboard after a one-out single, Nola successfully bunted a two-strike pitch from Lester and catcher Willson Contreras threw wildly to first for an error. McCutchen then hit a bouncer up the middle that looked like a possible inning-ending double play, but second baseman Daniel Descalso's throw pulled Rizzo off the bag at first.
Rodriguez scampered home to make it 5-0 Philadelphia. Segura followed with a long drive into the bleachers in left-center for his fifth homer for the NL East leaders.
"We had a couple of mistakes early, but the intensity of our guys is outstanding," Cubs manager Joe Maddon said.
That was the last inning for Lester, who was charged with four earned runs and seven hits in his second straight loss. The ace left-hander has allowed nine earned runs and 17 hits in his last two outings after yielding five earned runs and 35 hits in his first seven starts combined.
Lester was 8-0 with a 1.49 ERA in 10 career starts against the Phillies before Thursday.
"Something just doesn't feel right," Lester said. "The last two starts kind of speak for themselves. We've just got to figure it out."
Segura also doubled in the third to extend his hitting streak to 14 games. The shortstop is batting .325 in his first season with the Phillies.
Cubs star Kris Bryant was out of the starting lineup for rest. He walked as a pinch hitter in the sixth.
The Phillies optioned left-hander Cole Irvin to Triple-A Lehigh Valley and recalled right-hander Drew Anderson from their top farm club. Irvin started Wednesday's 8-4 loss and allowed seven runs in 4 2/3 innings.
Cubs: RHP Pedro Strop (left hamstring strain) is scheduled for another bullpen session Saturday. The Cubs haven't decided if Strop will go out on a minor league rehab assignment before returning to the team. "If they ask me, I'm going to say I don't need it," Strop said.
Phillies: Jerad Eickhoff (2-2, 3.23 ERA) takes the mound Friday night for the opener of a weekend series at Milwaukee. The right-hander allowed five runs in four innings in a 6-1 loss to the Brewers on May 14. Chase Anderson (2-0, 2.66 ERA) pitches for Milwaukee.
Cubs: Kyle Hendricks (4-4, 3.21 ERA) pitches Friday in the opener of a three-game series against Cincinnati. The right-hander is 3-0 with a 1.47 ERA in four May starts. Anthony DeSclafani (2-2, 4.60 ERA) gets the ball for the visiting Reds.
Jay Cohen can be reached at https://twitter.com/jcohenap
More AP MLB: https://apnews.com/MLB and https://twitter.com/AP-Sports
'Nervous' Machado back in Baltimore with Padres
Padres star Manny Machado admitted Tuesday to feeling "a little more nervous today" as he returned to Camden Yards for the first time since being traded from the Orioles to the Dodgers last July.
Rays owner 'asking for open minds' on Montreal plan
Rays owner Stu Sternberg explains why splitting home games between Tampa Bay and Montreal is best for the Rays.
Padres' Machado to face old team in Baltimore
The San Diego Padres do not come to Baltimore often. Still, when they meet the Orioles on Tuesday to start a brief two-game series, there will be a different feeling.
Astros ace Cole faces former Pirates teammates
The desperation was palpable. The Astros had dropped seven straight entering Sunday's series finale with the New York Yankees and faced the possibility of a winless road trip and the specter of carrying negative vibes back to Houston.
Hot-hitting Indians take aim at Royals again
Jason Kipnis and Jose Ramirez struggled early this season for the Cleveland Indians, but they are coming on fast now.
Yankees go for homer record vs. Blue Jays
For nearly a month, the New York Yankees have hit homers on a daily basis. Entering Monday, Giancarlo Stanton was not among the 12 Yankees to clear the fence in that stretch.