The fights are on ESPN+, with the main card starting at 8 p.m. ET and the prelims at 5 p.m.
Blaydes (12-2, 1 NC), No. 4 in the ESPN heavyweight rankings, has nine knockouts among his 12 victories. He has won two in a row.
Dos Santos (21-6), a former UFC heavyweight champion, is No. 5 in the ESPN rankings. He saw a three-fight winning streak snapped in June by Francis Ngannou.
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Fans can check out FightCenter for live coverage of the event.
UFC Fight Night: Blaydes vs. Dos Santos
ESPN+, 8 p.m. ET
Curtis Blaydes vs. Junior dos Santos | Heavyweight
Rafael dos Anjos vs. Michael Chiesa | Welterweight
Jordan Espinosa vs. Alex Perez | Men's flyweight
Hannah Cifers vs. Angela Hill | Strawweight
Jamahal Hill vs. Darko Stošić | Light heavyweight
ESPN+, 5 p.m.
Bevon Lewis vs. Dequan Townsend | Middleweight
Arnold Allen vs. Nik Lentz | Men's featherweight
Justine Kish vs. Lucie Pudilová | Women's flyweight
Montel Jackson vs. Felipe Colares | Men's bantamweight
Sara McMann vs. Lina Länsberg | Women's bantamweight
Brett Johns vs. Tony Gravely | Men's bantamweight
Herbert Burns vs. Nate Landwehr | Men's featherweight