Love has been sick the past two days, and Cleveland coach John Beilein is hoping another day's rest will help his best player recover.
Beilein said Love could rejoin the team in time for Saturday night's game at Philadelphia.
Love is averaging 16.7 points and 10.7 rebounds for the young Cavs. They have now dropped five straight games and 11 of their last 12.
Love missed three games recently with a bruised back. He scored just eight points in 21 minutes in Tuesday's lopsided loss to Detroit.