Butler didn't travel with the team for Monday night's game. He also didn't play Saturday night when the Heat routed the Cavaliers 124-105 in Miami.
Butler, who leads the Heat in scoring, played in the All-Star Game and scored 17 points in Miami's first game after the All-Star break against Atlanta.
The 6-foot-7 guard/forward is averaging 20.6 points, 6.9 rebounds and 6.2 assists.
Miami is 36-21 and in fourth place in the Eastern Conference.
Wednesday's matchup with Minnesota marks the beginning of a five-game homestand for the Heat.
The Associated Press contributed to this report.