James, 35, missed 27 games last season because of a groin injury suffered Christmas Day. This season, he sat out games in December and February for the same reason.
James has averaged 33.5 minutes in the Lakers' four games since the season restart, scoring nearly 20 points per game.
The Lakers, who have already clinched the No. 1 seed in the Western Conference, are 2-2 in the Orlando bubble and have struggled on offense. They are the only team out of the 22 participating in the restart averaging less than 100 points per game.
Lakers backup guard Alex Caruso (neck muscle spasms), who was listed as questionable, did not play against Houston.
Point guard Russell Westbrook missed Thursday's game for the Rockets because of a right quadriceps contusion.
Information from ESPN's Tim MacMahon was used in this report.