Clippers coach Ty Lue said that George tweaked his ankle during the Clippers' 112-107 victory in Phoenix on Sunday. George, who scored 39 points in 38 minutes during the win over the Suns, tested his ankle before the team made its decision prior to the game.
George is averaging 25.1 points, 5.7 rebounds and 5.1 assists this season. Luke Kennard started against San Antonio in George's place.
The Clippers play the second game of a back-to-back set at Golden State on Wednesday.