Manning will miss James

Late in the 2005 regular season, the Indianapolis Colts were sitting on top of the NFL world. They were 13-0 and talk centered on whether they could become the greatest team ever.

Unfortunately, the Colts began to lose their way in the final three weeks, with losses to the Chargers and Seahawks, and were promptly eliminated in the divisional playoffs by the Steelers. Nevertheless, Indianapolis had an excellent football team and was expected to keep its roster intact.

However, the Colts made a critical mistake this offseason, triggering a chain of events that could make them extremely vulnerable. In opting to open up the vault for WR Reggie Wayne, the Colts lost star RB Edgerrin James and two key defensive players -- SLB David Thornton and DT Larry Tripplett.