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Biggest 2020 NFL QB matchups: In-depth look at Mahomes-Jackson, Brady-Brees, more

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Orlovsky on Mahomes' extension: 'This is awesome' (1:13)

Dan Orlovsky explains why Patrick Mahomes' 10-year extension with the Chiefs is good for all parties involved. (1:13)

With unprecedented offseason quarterback movement comes Tom Brady in a new conference.

Instead of games against the "who's that?" QBs of the AFC East, he'll now match up twice a season with the likes of a couple of fellow future Hall of Famers.

There are some more great QB matchups headed our way, including the NFL's new $500 million man against the reigning MVP and possibly the first two signal-callers taken in this year's draft.

ESPN Stats & Info delved deeply into several of the duels on the slate for 2020. Here's some of what was uncovered.

Henry Buggy, Jose De Leon, Douglas Clawson, Bryan Beasley, Will Erickson and Evan Kaplan contributed to this story.

Tom Brady vs. Drew Brees

Tampa Bay Buccaneers at New Orleans Saints

Date: Sept. 13 | Network: Fox

Historic matchup: Brady and Brees kick things off with a Week 1 meeting in New Orleans. It will mark the first matchup between 40-year-old starting QBs in NFL history. The two will meet again in Week 9, as both QBs look to lead their teams to the top of the NFC South.

Brees and Brady are No. 1 and No. 2 respectively in passing yards, passing TDs and completions. In fact, their 151,987 combined passing yards measure out to just over 86 miles, more than enough to reach outer space.

Per the Elias Sports Bureau, the Week 1 matchup between Brees and Brady will be the first between the top two all-time leaders in passing yards since Hall of Famers Dan Marino and John Elway met in Week 16 of the 1998 season. It's also the first matchup between the top two all-time leaders in touchdown passes since Sid Luckman (Bears) and Sammy Baugh (Redskins) squared off on Nov. 20, 1949. Prior to Brady and Brees, the last time the top two in passing TDs were both active was in 1973 (Johnny Unitas and Fran Tarkenton).

The two have more combined passing touchdowns (1,088) than seven NFL franchises (Bengals, Seahawks, Buccaneers, Panthers, Ravens, Jaguars and Texans). In fact, individually Brady and Brees have more passing touchdowns than the Panthers, Ravens, Jaguars and Texans have in their franchise's history.

Brady has 14 Pro Bowl selections in his career, tied with Peyton Manning for the most by any QB in NFL history, while Brees has 13 Pro Bowl selections in his career, third most by a QB. According to Elias, their combined 27 Pro Bowl selections will be the most ever in a matchup of starting QBs, surpassing Brady's previous records with Brees in 2017 and Manning in 2014 (22 combined in both those matchups).

Previous meetings: Week 1 will mark the sixth meeting between Brady and Brees, with Brees holding a 3-2 edge. One of those wins came as the starting QB of the Chargers. Of the 14 QBs to have faced Brady at least five times in the regular season, Brees is the only one with a winning record. In their head-to-head matchups, Brees has thrown 12 touchdowns to 1 interception, while Brady has 7 passing touchdowns to 6 interceptions. But Brady has won the past two meetings, and the last time he faced the Saints in the Big Easy (Week 2 of 2017), he posted his highest single-game Total QBR (96.1) on the road over the past decade.