<
>
EXCLUSIVE CONTENT
Get ESPN+

Fantasy fallout: Are RB replacements for Giants, Panthers, 49ers worth using?

play
How much will the Panthers struggle without McCaffrey? (0:37)

Ryan Clark explains why the Panthers will have a hard time competing while Christian McCaffrey is sidelined for multiple weeks. (0:37)

Nobody has a more stacked lineup of fantasy analysts and NFL team reporters than ESPN. It's the rare backfield-by-committee that's actually a good thing for fantasy managers. Every Tuesday, we'll ask our NFL Nation reporters a series of burning questions to help inform your waiver-wire pickups and roster decisions.

Ouch.

Unfortunately, injuries are part of the game. But this week was particularly brutal, with the top two draft picks from most fantasy leagues both being sidelined. Carolina Panthers running back Christian McCaffrey will miss "multiple weeks" with a high ankle sprain, while New York Giants running back Saquon Barkley will miss the remainder of the season with a torn ACL.

Another running back who was off to a sizzling start -- the San Francisco 49ers' Raheem Mostert -- is also expected to miss at least one week with a knee sprain.

Here is how the Giants, Panthers and 49ers plan to replace their backs in real life: