The Colts also activated cornerback Jackson Porter from the reserve/COVID-19 list.
He also displayed more versatility, playing both in the box as a run-stopper and out of it as a safety who could defend tight ends.
Wilson was taken in the second round by New England in 2012 out of Illinois and primarily played special teams. He flourished after signing with Detroit in 2016, winning a safety job opposite Quin his first season and becoming a key contributor since.
The Washington, D.C., native has played in 110 career games, starting 43. He has 8 interceptions, 19 passes defensed, 5 sacks, and 351 tackles in his career.
ESPN's Michael Rothstein contributed to this report.