Patterson has been dealing with an ankle injury, and on Wednesday, head coach Arthur Smith said he would take the decision up to game time.
Patterson, the Falcons' second-leading receiver and leading rusher, is in the midst of a career year. The 30-year-old utility player already has 473 receiving yards and 303 rushing yards, eclipsing the season highs in his prior eight years. He has also scored seven total touchdowns, equaling the TDs scored in his rookie year in 2013.
Without Patterson, Atlanta will rely on Mike Davis, Wayne Gallman and practice squad call-up Qadree Ollison for rushing duties. The team also elevated receiver Marvin Hall, a potential downfield threat, to give Atlanta another receiving option along with Russell Gage, Olamide Zaccheaus and Tajae Sharpe.