Coming off his second game with the Rams, Beckham is dealing with a hip injury and Henderson has a thigh injury.
McVay said that he would be surprised if Beckham were unable to play, but added that Henderson would be further evaluated during Friday's practice.
The Rams are 7-4 and have lost three straight as they prepare for the 2-9 Jaguars at SoFi Stadium.
Beckham's practice participation has been uneven throughout the week after he caught five passes for 81 yards and a touchdown in a 36-28 loss to the Green Bay Packers last Sunday. The eighth-year pro practiced in a limited capacity Wednesday, but did not practice Thursday, which typically is the Rams' heaviest workload day of the week.
The Rams receivers group has been hit with a rash of injuries that have left them thin at the position.
Three weeks ago, on the same day the Rams signed Beckham to a free-agent deal, veteran receiver Robert Woods suffered an ACL tear in his left knee that has sidelined him for the season. Prior to Woods' injury, rookie Tutu Atwell, a second-round pick from Louisville, was placed on injured reserve because of a shoulder injury.
The Rams also released receiver DeSean Jackson after the trade deadline after they were unable to find a trade partner following the veteran receiver's request to seek a new opportunity.
If Beckham is unable to play, the Rams will depend on rookie Ben Skowronek, a seventh-round pick from Notre Dame who recently has dealt with a back issue, to step in alongside Cooper Kupp and Van Jefferson. J.J. Koski, an undrafted free agent, could also be used as a role player.
If Henderson can't play, expect Sony Michel to start. Michel has rushed for 305 yards and a touchdown since he was traded to the Rams before the season.