Lance shared snaps with starting quarterback Jimmy Garoppolo in the first quarter of the season opener.
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Deebo Samuel is among the top point-getters at receiver, Sam Darnold looks improved and Devin Singletary has stepped it up a notch.
The 49ers have already ruled out RB JaMycal Hasty for next week's game against the Packers but said rookies Elijah Mitchell and Trey Sermon have a chance to play.
The 49ers won a "grimy" defensive game against the Eagles one week after outlasting the Lions in a game marked by offense.
San Francisco's Elijah Mitchell suffered a right shoulder injury in the 49ers' victory over the Eagles in Philadelphia on Sunday, another in a long line of backfield injuries that have plagued coach Kyle Shanahan's 2-0 club.
Week 2 takeaways and big questions: Patriots' big day, Ravens beat Chiefs and a shocker for the Saints
New England and Buffalo dominated, while New Orleans looked out of sorts and Green Bay got back on track. Here's what to know and what it means going forward for every Week 2 game.
Tristan H. Cockcroft ESPN Senior Writer
Through two weeks, Brandon Aiyuk, the WR23 on average in ESPN leagues, has a total of 31 routes, two targets and 1.60 PPR fantasy points. It's hard to fathom how little he has been involved in the San Francisco offense.
— Jimmy Garoppolo wasn't thinking about Trey Lance coming into the game. He was too busy using his own legs to convert first downs.
Nick Wagoner ESPN Staff Writer
49ers inactives: CB Emmanuel Moseley (knee), OL Aaron Banks, CB Ambry Thomas, DT Zach Kerr.
Adam Schefter ESPN Senior Writer
Veteran CB Josh Norman, who signed with the 49ers less than two weeks ago, is expected to start today at Philadelphia against the Eagles, per source.
For the second straight year, the 49ers' stay at the West Virginia-based Greenbrier meant the team was nursing multiple injuries to key players.
Is Nelson Agholor the Patriots' No. 1 wideout? What's the deal with Brandon Aiyuk in San Francisco? Our reporters fill you in before Sunday's games.
Our NFL team reporters round up injury updates for key players in Week 2.
Anyone who follows football and can fog a mirror knows that winning the turnover battle is important.
San Francisco 49ers LB Dre Greenlaw will miss extended time because he's slated to have surgery to repair a groin injury, a league source confirmed to ESPN.
Niners coach Kyle Shanahan isn't hesitating to work Lance into the offense because of the threat he presents as a runner.
No contribution was too small as these first-year QBs begin their promising careers.
San Francisco 49ers running back Raheem Mostert announced Tuesday that he will undergo season-ending knee surgery after consulting with multiple doctors.
This Just In
49ers RB Raheem Mostert announces he is out for the season. In a social media post, he wrote: "I'm gutted. This sucks! This is obviously not what I worked so hard for. I wish more than anything I could be out there with my brothers. Thank you for your support in our decision. I'M FAR FROM DONE!"
DeVonta Smith found the end zone, Mac Jones showed poise for the Pats, and Joe Tryon-Shoyinka made his mark on the veteran Super Bowl champs.
How did the rookie starters look in Week 1? What did Trevor Lawrence, Zach Wilson and Mac Jones do well -- and not so well? Plus, when will Trey Lance and Justin Fields start?