Bart Ogbeche scored his first hat-trick of the season, with Aniket Jadhav grabbing the other goal.
The former India midfielder was suffering from kidney and diabetes related ailments for a long time.
The Mario Rivera era at SC East Bengal began on a winning note, thanks to Naorem Mahesh's brace.
The victory allowed Owen Coyle's men to leapfrog the competition and reach first place in the points table with 19 points.
As we cross the half-way mark of the league stage, here's our report card for each of the 11 teams.
Mumbai City have now gone four games without a win, while SC East Bengal remain winless this season.
Bengaluru remain eighth in the league while SCEB remain bottom of the table.
Rivera had guided East Bengal to a second-place finish in the I-League two seasons back.
SC East Bengal are bottom of the table and without a win under Manolo Diaz this season.
Hyderabad extended their unbeaten run to six games but East Bengal remain winless in eight matches.
Alvaro Vazquez and Tomislav Mrcela found the net in an entertaining draw.
Goals from Alberto Noguera (2), Jorge Ortiz and an Antonio Perosevic own goal saw Goa register their first win of the season.
Suvam Sen and Vishal Kaith stood out in both goals as the game finished goalless, despite 35 shots in total.
Odisha beat SC East Bengal 6-4 in a match that saw five goals scored after the 80th minute.
Antonio Habas' metamorphosis into a manager overseeing an attacking, fluid ATK Mohun Bagan left SC East Bengal in shreds in the Kolkata Derby.
Roy Krishna, Manvir Singh and Liston Colaco found the net as ATK Mohun Bagan dominated the Kolkata Derby.
PLUS: Concerns reign for Bengaluru & Chennaiyin, while Odisha bring a welcome surprise - in this week's ISL musings.
We look at key factors for each of the 11 teams in the Indian Super League this season.
Bio-bubbles again, Goa again, but a whole host of changes to the teams - here's how things stack up ahead of the new season.
East Bengal terminated Robbie Fowler's contract on Wednesday, following a ninth-placed finish in ISL last season.
East Bengal supporters clashed over the impasse between East Bengal and investors Shree Cement.
The clubs can't sign new players in the transfer window because of non-payment of dues to former recruits.
The EC has threatened to resign if they are forced to sign the final agreement with investors Shree Cements.
With the ISL league stage over, we take a look at how each team has performed this season.
PLUS: Odisha finish in style and Hyderabad win everyone's heart in this week's ISL musings.