Colombia's scoring troubles continued as their World Cup hopes took a dip against a resurgent Peru.
Edison Flores scored a late goal for Peru to give the Andean side a 1-0 win away at Colombia.
Brazil had themselves a feisty match with Ecuador while Argentina looked strong against Chile, but it was Uruguay who boosted their World Cup hopes.
Goals from Angel Di Maria and Lautaro Martinez gave Argentina a 2-1 win in Chile on Thursday in their CONMEBOL World Cup qualifier.
Brazil had to settle for a 1-1 draw away to Ecuador after Felix Torres' header 15 minutes from time cancelled out an early Casemiro strike.
Brazil coach Tite believes Philippe Coutinho can help make up for the loss of injured Neymar in their upcoming 2022 World Cup qualifiers.
South America's World Cup qualification campaign has entered the home straight, and things are looking desperate for some of the heavyweights.
Carlo Ancelotti hit out at the "crazy" football calendar which could see Real Madrid's South American players miss the Copa del Rey quarterfinal.
Lionel Messi has been left off Argentina's World Cup qualifiers against Chile and Colombia to rebuild his match fitness at Paris Saint-Germain.
Tite has an unenviable collection of attacking talent, but Vinicius has played his way into contention and could ease the pressure on Neymar.
Brazil coach Tite has recalled Dani Alves for the final two World Cup qualifiers against Ecuador and Paraguay.
Philippe Coutinho's struggles at Barcelona are souring his World Cup hopes with Brazil. Could a reunion with Steven Gerrard at Aston Villa fix that?
Uruguay coach Diego Alonso has had an interesting career and follows a living legend. Can he get the squad back on track and reach the World Cup?
Former Inter Miami and Monterrey manager Diego Alonso has been named the new coach of Uruguay, the country's football association said on Tuesday.
FIFA president Gianni Infantino has advocated hosting the World Cup biennially as a move that will help smaller nations achieve their dreams.
The U.S. or Mexico could face a winner-takes-all match against a team from Oceania if either side doesn't directly qualify for the World Cup.
Oscar Tabarez dreamt of Uruguay contesting Qatar 2022 with a squad of veteran stars and promising kids. They may still, but he won't be their coach.
Uruguay coach Oscar Tabarez was fired Friday amid his team's poor run in World Cup qualifying.
FIFA changed the World Cup qualifying format for the intercontinental playoffs on Friday to be single-leg games at a neutral venue.
Officials Andres Cunha and Esteban Ostojich were suspended after failing to give a red card to Argentina's Nicolas Otamendi vs. Brazil.
Argentina, amid a 27-game unbeaten run, have qualified for Qatar 2022. For Uruguay, however, things are starting to turn sour.
Argentina and Brazil drew a tense and end-to-end match 0-0 on Tuesday, meaning both teams retained their unbeaten record in CONMEBOL WC qualifiers.
Bolivia scored twice in the first half then missed a penalty and had a man sent off in a 3-0 win over Uruguay on Tuesday.
Argentina captain Lionel Messi is fit again and will start their World Cup qualifier at home to Brazil on Tuesday but Neymar will miss out.