Per Orlando City, Dwyer has ventured home and will not return in time with respect to the injury and quarantine.
Dwyer, who has missed the team's last two matches, last participated in Orlando City's 3-1 win over New York City FC on July 14.
The 29-year-old has notched an assist in two matches this season for Orlando City (2-1-2, 8 points), who posted a 1-0 win over the Montreal Impact on Saturday. The Lions will play against the winner of Monday's match between the Seattle Sounders and Los Angeles FC in the quarterfinals on Friday.
Dwyer has recorded 81 goals and 18 assists in 195 career matches with Sporting Kansas City and Orlando City.