Olympique Lyonnais's mediocre Ligue 1 season continued when they slumped to a 1-0 home defeat against Stade Rennais and lost both Memphis Depay and Jeff Reine-Adelaide for the remainder of the season on Sunday.
Dutch striker Depay's knee injury now even makes him a major doubt for the Euro 2020 finals that start on June 12.
Eduardo Camavinga scored the only goal from just inside the box with one minute left to lift Rennes up to fourth on 30 points from 17 games.
Lyon, who have been at odds with some of their own fans recently despite qualifying for the Champions League last 16, slipped down to eighth with 25 points from 18 matches.
The evening took a calamitous turn for the hosts when Dutch forward Depay, who has scored nine league goals this season, had to be replaced at halftime with a cruciate knee ligament injury.
That blow came after midfielder Reine-Adelaide was also forced to leave the pitch with a similar injury.
"They should be out of action for at least six months," OL said in a statement.
Lyon remained toothless after the break and some sloppy defending allowed Camavinga to enter the area and fire a last-gasp winner.