Francisco Ginella added his first career MLS goal in the 65th minute and Pablo Sisniega made four saves for LAFC (7-6-3, 24 points), who averted a three-game regular-season sweep by Seattle. The Sounders (9-4-3, 30 points) posted a 3-1 win over LAFC on Aug. 30 and a 3-0 victory on Sept. 18, although LAFC recorded a 4-1 triumph over Seattle in the Round of 16 of the MLS is Back Tournament on July 27.
LAFC played without four of their top on-field producers who were competing in the CONMEBOL 2022 World Cup qualifiers. Their absences ultimately led to Musovski making the start.
Musovski didn't disappoint, as he gained a step on his defender and headed home Eduard Atuesta's kick off a set piece to open the scoring in the 15th minute.
Ginella doubled the advantage 50 minutes later by unleashing a right-footed shot from outside the box that caught Frei flat-footed.
Lodeiro converted a free kick in the 77th minute for his fifth goal of the season and third versus LAFC.
Musovski regained the two-goal edge seven minutes later for LAFC after settling a rebound of Latif Blessing's shot before sending the ball inside the left post. The goal was the 24-year-old Musovski's fourth of the season.
LAFC's victory was all-the-more impressive after they sustained a pair of injuries in the early going. Mark-Anthony Kaye exited with an apparent ankle ailment following a collision with Seattle's Yeimar Gomez Andrade. He initially was replaced by Andy Najar, who sustained an apparent hamstring injury.