With Brazil into the World Cup and Argentina on the verge, teams such as Ecuador, Colombia, Chile, and Uruguay are fighting for their spots.
Peru missed a penalty in a 1-0 loss to Argentina in Buenos Aires on Thursday, delivering another blow to their hopes of World Cup qualification.
Brazil are leading the way in CONMEBOL qualifying, but what about the rest as this week's tripleheaders see two-thirds of games complete?
Everton Ribeiro got his second goal in two games to help Brazil on their way to a 2-0 win over Peru in a World Cup qualifier in Recife on Thursday.
The suspension of Argentina vs. Brazil took the spotlight off a competitive South American World Cup qualifying, but all eyes are back on the pitch.
Brazil are comfortably out front of South America's World Cup qualifying campaign, but behind them, a lot could change between now and Qatar 2022.
Luis Diaz scored a second-half double, the second an unstoppable 25-metre strike in injury time, to give Colombia a 3-2 win over Peru on Friday.
Monday's Copa semi started to look like a training game, but Peru turned into a tense struggle that left Brazil thankful to hear the final whistle.
Brazil were made to work as the reached the Copa America final with a win against Peru on Monday night in Rio.
Brazil midfielder Lucas Paqueta helped his side beat Chile, while Peru overcame Paraguay on penalties.
Peru beat Paraguay 4-3 on penalties to move into the Copa America semifinals on Friday following an action-packed match that ended 3-3.
Will Neymar lead Brazil to another Copa America crown, or will Lionel Messi finally win his first senior international title with Argentina?
Neymar is in form, Leo Messi is breaking records, but it's the displays of Ricardo Gareca's Peru that have been the talk of the Copa group stage.
Peru beat Venezuela 1-0 in the Copa America on Sunday, sealing their place in the last eight of the competition in the final round of group matches.
Peru scored two goals in the second half to rescue a 2-2 draw against Ecuador in the Copa America on Wednesday.
Uruguay's Facundo Torres and Ecuador's Gonzalo Plata may be inconsistent, but they are making people sit up and take notice at the Copa America.
There were 140 known COVID-19 cases at the Copa America in Brazil on Monday, up from 66 positive tests on Thursday.
Yerry Mina's own goal in the second half saw Colombia crash to a 2-1 defeat by Peru in an absorbing Copa America clash on Sunday.
The second set of Copa America matches saw Argentina get their first win of the tournament while hosts Brazil scored another big victory.
Neymar and Alex Sandro scored for Brazil as they beat Peru on Thursday night to maintain a perfect start to their 2021 Copa America campaign.
Half of the teams playing the Copa America -- Venezuela, Bolivia, Colombia, Peru and Chile -- have confirmed at least one positive test.
The first set of Copa America matches have concluded. As Brazil still struggles with COVID-19 cases, the on-field action is officially underway.
After a long and controversial saga, the Copa America will kick off. Will Brazil repeat as winners or can Lionel Messi lead Argentina to glory?
Brazil's Supreme Court on Thursday rejected all three injunctions sought to prevent the Copa America tournament being held in the country.