Germany manager Joachim Low slammed striker Timo Werner's close-range miss in the shock loss to North Macedonia.
North Macedonia scored an 85th-minute winner through Eljif Elmas to stun hosts Germany 2-1 in their World Cup Group J qualifier.
North Macedonia qualified for Euro 2020, their first-ever major tournament, with a second-half goal from 37-year-old forward Goran Pandev.
Hungary, Iceland, Scotland, Northern Ireland, Serbia, Slovakia, North Macedonia, and Georgia all advanced to the Euro 2020 playoff finals.
David Alaba's early goal and a snap effort from Stefan Lainer in the second half ensured Austria qualified for next year's European Championship.
Poland left it late before goals from substitutes Przemyslaw Frankowski and Arkadiusz Milik gave them a 2-0 win over North Macedonia.
Poland beat North Macedonia 1-0 away on Friday to remain top of Euro 2020 qualifying Group G with their third win in three games.
Gian Piero Ventura's misfiring Italy limped into the uncertainty of the World Cup qualifying playoffs after being held to a 1-1 draw by Macedonia.
David Silva and Diego Costa were on target but Spain made hard work of seeing off Macedonia in Skopje.
Belgium edged the Czech Republic 2-1 in a friendly with Michy Batshuayi and Marouane Fellaini making the difference.
The video assistant referee twice played an important role as Spain beat France 2-0 in a friendly in Paris on Tuesday.
Gianluigi Buffon kept a clean sheet in his 1,000th professional appearance for club and country as Italy beat Albania 2-0 in a World Cup qualifier.
Spain's 4-0 win over Macedonia -- their 93rd home victory in a qualifying campaign -- set a new all-time record.
Celta Vigo striker Iago Aspas' unexpected call up to the Spain squad for the World Cup qualifier against Macedonia surprised even him.